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Pt–Ba–Ce/γ-Al₂O₃ 催化剂，物理化学性质，NO_x存储和还原，NO_x 排放，H₂ 还原剂 1

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Achievements, challenges and global implications of China’s carbon neutral pledge

《环境科学与工程前沿（英文）》 2022年第16卷第8期 doi: 10.1007/s11783-022-1532-9

摘要： China has been committed to achieving carbon neutrality by 2060. China’s pledge of carbon neutrality will play an essential role in galvanising global climate action, which has been largely deferred by the Covid-19 pandemic. China’s carbon neutrality could reduce global warming by approximately 0.2–0.3 °C and save around 1.8 million people from premature death due to air pollution. Along with domestic benefits, China’s pledge of carbon neutrality is a “game-changer” for global climate action and can inspire other large carbon emitters to contribute actively to mitigate carbon emissions, particularly countries along the Belt and Road Initiative (BRI) routes. In order to achieve carbon neutrality by 2060, it is necessary to decarbonise all sectors in China, including energy, industry, transportation, construction, and agriculture. However, this transition will be very challenging, because major technological breakthroughs and large-scale investments are required. Strong policies and implementation plans are essential, including sustainable demand, decarbonizing electricity, electrification, fuel switching, and negative emissions. In particular, if China can peak carbon emissions earlier, it can lower the costs of the carbon neutral transition and make it easier to do so over a longer time horizon. China’s pledge of carbon neutrality by 2060 and recent pledges at the 26^th UN Climate Change Conference of the Parties (COP26) are significant contributions and critical steps for global climate action. However, countries worldwide need to achieve carbon neutrality to keep the global temperature from growing beyond the level that will cause catastrophic damages globally.

关键词： Carbon neutrality Carbon peak Renewable energy Negative emission Carbon capture Utilisation and storage Nature-based solution

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Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

《医学前沿（英文）》 doi: 10.1007/s11684-023-1016-8

摘要： p53 is mutated in half of cancer cases. However, no p53-targeting drugs have been approved. Here, we reposition decitabine for triple-negative breast cancer (TNBC), a subtype with frequent p53 mutations and extremely poor prognosis. In a retrospective study on tissue microarrays with 132 TNBC cases, DNMT1 overexpression was associated with p53 mutations (P = 0.037) and poor overall survival (OS) (P = 0.010). In a prospective DEciTabinE and Carboplatin in TNBC (DETECT) trial (NCT03295552), decitabine with carboplatin produced an objective response rate (ORR) of 42% in 12 patients with stage IV TNBC. Among the 9 trialed patients with available TP53 sequencing results, the 6 patients with p53 mutations had higher ORR (3/6 vs. 0/3) and better OS (16.0 vs. 4.0 months) than the patients with wild-type p53. In a mechanistic study, isogenic TNBC cell lines harboring DETECT-derived p53 mutations exhibited higher DNMT1 expression and decitabine sensitivity than the cell line with wild-type p53. In the DETECT trial, decitabine induced strong immune responses featuring the striking upregulation of the innate immune player IRF7 in the p53-mutated TNBC cell line (upregulation by 16-fold) and the most responsive patient with TNBC. Our integrative studies reveal the potential of repurposing decitabine for the treatment of p53-mutated TNBC and suggest IRF7 as a potential biomarker for decitabine-based treatments.

关键词： p53 mutation triple-negative breast cancer decitabine DNMT1 IRF7 innate immune response

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负能量问题——超光速研究的重要方向

黄志洵

《中国工程科学》 2001年第3卷第7期页码 42-47

摘要：

论述了关于负能量的多个理论预期和相关实验，阐明了超光速研究和负能量概念的关系。

关键词：负能量超光速 Casimir效应消失模负折射率

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Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

《医学前沿（英文）》 2021年第15卷第1期页码 1-10 doi: 10.1007/s11684-020-0741-5

摘要： Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with a heterogeneous genetic profile. Chemotherapy exhibits substantial activity in a small subset of these patients. Drug resistance is inevitable. Major progress has been made in the genetic analysis of TNBC to identify novel targets and increase the precision of therapeutic intervention. Such progress has translated into major advances in treatment strategies, including modified chemotherapy approaches, immune checkpoint inhibitors, and targeted therapeutic drugs. All of these strategies have been evaluated in clinical trials. Nevertheless, patient selection remains a considerable challenge in clinical practice.

关键词： triple-negative breast cancer immunotherapy targeted therapy

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Field validation of UHPC layer in negative moment region of steel-concrete composite continuous girder

Minghong QIU; Xudong SHAO; Weiye HU; Yanping ZHU; Husam H. HUSSEIN; Yaobei HE; Qiongwei LIU

《结构与土木工程前沿（英文）》 2022年第16卷第6期页码 744-761 doi: 10.1007/s11709-022-0843-z

摘要： Improving the cracking resistance of steel-normal concrete (NC) composite beams in the negative moment region is one of the main tasks in designing continuous composite beam (CCB) bridges due to the low tensile strength of the NC deck at pier supports. This study proposed an innovative structural configuration for the negative bending moment region in a steel-concrete CCB bridge with the aid of ultrahigh performance concrete (UHPC) layer. In order to investigate the feasibility and effectiveness of this new UHPC jointed structure in the negative bending moment region, field load testing was conducted on a newly built full-scale bridge. The newly designed structural configuration was described in detail regarding the structural characteristics (cracking resistance, economy, durability, and constructability). In the field investigation, strains on the surface of the concrete bridge deck, rebar, and steel beam in the negative bending moment region, as well as mid-span deflection, were measured under different load cases. Also, a finite element model for the four-span superstructure of the full-scale bridge was established and validated by the field test results. The simulated results in terms of strains and mid-span deflection showed moderate consistency with the test results. This field test and the finite element model results demonstrated that the new configuration with the UHPC layer provided an effective alternative for the negative bending moment region of the composite beam.

关键词： field test steel-concrete composite beam continuous girder bridge negative bending moment region ultrahigh performance concrete

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Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breastcancer was similar in node-negative diseases: a single-center study of 800 patients

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

《医学前沿（英文）》 2021年第15卷第4期页码 621-628 doi: 10.1007/s11684-020-0738-0

摘要： Multi-gene assays have emerged as crucial tools for risk stratification in early-stage breast cancer. This study aimed to evaluate the prognostic significance of the 21-gene recurrence score (RS) in Chinese patients with pN0-1, estrogen receptor-positive (ER ), human epidermal growth factor receptor 2-negative (HER2 ) breast cancer. Among 800 patients recruited between 2009 and 2016, the median RS was 24 (0–69), with 27.4%, 46.8%, and 25.9% patients classified into low-, intermediate-, and high-risk groups. Cox regression analysis demonstrated that the high-risk category was associated with significantly higher odds of invasive disease-free survival (IDFS) and distant disease-free survival (DDFS) events compared with the low-risk category (IDFS: HR= 2.450, 95% CI 1.017–5.902, = 0.046; DDFS: HR= 2.829, 95% CI 1.013–7.901, = 0.047). No significant association between RS category and overall survival (OS) was found (intermediate vs. low: HR= 1.244, 95% CI 0.292–5.297, = 0.768; high vs. low: HR= 2.933, 95% CI 0.759–11.327, = 0.119). RS, as a continuous variable, was a highly significant predictor for IDFS (HR= 1.028, 95% CI 1.010–1.047, = 0.002), DDFS (HR= 1.030, 95% CI 1.010–1.051, = 0.003), and OS (HR= 1.034, 95% CI 1.007–1.063, = 0.014). Our findings suggested that RS may predict IDFS in Chinese patients with ER /HER2 breast cancer with N0 or N1 disease.

关键词： early breast cancer 21-gene assay recurrence score prognosis

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硅微z轴谐振陀螺仪负电刚度效应分析及实验验证

夏敦柱,周百令,王寿荣

《中国工程科学》 2007年第9卷第8期页码 66-68

摘要：

介绍了在开环工作状态下硅微z轴谐振陀螺仪由于加工工艺缺陷所导致的误差机理。为减小陀螺仪初始电容差和抑制正交耦合误差，提出了一种闭环控制检测策略。重点分析了其力矩反馈器的电刚度效应并给出其线性数学模型表示式。通过对硅微z轴陀螺仪敏感模态的反馈力与谐振频率的关系分析，间接得出了在敏感方向上电负刚度与力矩器所施电压的内在联系，并在实验上进一步验证电刚度效应。这将为下一步闭环控制方案的设计奠定重要基础。

关键词：硅微z轴陀螺仪负电刚度力矩反馈器微机电系统

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物理光学的若干进展

黄志洵

《中国工程科学》 2006年第8卷第2期页码 18-29

摘要：

就物理光学方面的一系列理论和实验研究，如Goos-Hänchen位移、FTIR现象、负折射率、太赫超光速实验、光子静质量测量等做了评述和讨论。指出近年来的研究显示了消失波现象的重要性，例如消失波可造成超光速传播，且常有新方法和新测量结果；介绍了物理光学在相关领域的技术创新和应用实例；讨论了光子有静止质量的可能性及光频标准和光频测量的历史和新的进展。

关键词：物理光学负波速负折射率 GH位移消失波光子静质量

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大直径盾构负环管片拆除及隧道换装技术

翟志国,黄学军,杨志永

《中国工程科学》 2010年第12卷第12期页码 83-88

摘要：

通过对北京铁路地下直径线2标工程的研究，确定在刀盘改造期间进行负环管片拆除的一系列工作，重点如部分反力架的拆除方法、负环管片的详细拆除方法以及拆除反力架后临时支撑的架设方法，同时就泥水盾构隧道的换装技术进行了叙述，最终在7 d之内成功拆除了7环负环管片，节约了工期，保证了后继施工的材料运输速度。

关键词：大直径盾构负环管片拆除隧道换装

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A new prediction method of industrial atmospheric pollutant emission intensity based on pollutant emission

《环境科学与工程前沿（英文）》 2023年第17卷第1期 doi: 10.1007/s11783-023-1608-1

摘要：

● Established a quantification method of pollutant emission standard.

关键词： Industrial atmospheric pollutants Pollutant emission standards Quantitative method Machine learning Single enterprise

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homogeneous charge compression ignition combustion in a two-cylinder gasoline direct injection engine with negative

WANG Zhi, WANG Jianxin, SHUAI Shijin, MA Qingjun, TIAN Guohong

《能源前沿（英文）》 2007年第1卷第3期页码 311-315 doi: 10.1007/s11708-007-0045-3

摘要： Homogeneous charge compression ignition (HCCI) has challenges in ignition timing control, combustion rate control, and operating range extension. In this paper, HCCI combustion was studied in a two-cylinder gasoline direct injection (GDI) engine with negative valve overlap (NVO). A two-stage gasoline direct injection strategy combined with negative valve overlap was used to control mixture formation and combustion. The gasoline engine could be operated in HCCI combustion mode at a speed range of 800–2 200 r/min and load, indicated mean effective pressure (IMEP) range of 0.1–0.53 MPa. The engine fuel consumption is below 240 g/(kW

关键词： Homogeneous control combustion consumption extension

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利用负排放技术减缓气候变化

Chris Palmer

《工程（英文）》 2019年第5卷第6期页码 982-984 doi: 10.1016/j.eng.2019.10.006

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Dissolved methane in anaerobic effluent: Emission or recovery?

《环境科学与工程前沿（英文）》 2022年第16卷第4期 doi: 10.1007/s11783-022-1537-4

摘要： Various anaerobic processes have been explored for the energy-efficient treatment of municipal wastewater. However, dissolved methane in anaerobic effluent appears to be a barrier towards the energy and carbon neutrality of wastewater treatment. Although several dissolved methane recovery methods have been developed, their engineering feasibility and economic viability have not yet been assessed in a holistic manner. In this perspective, we thus intend to offer additional insights into the cost-benefit of dissolved methane recovery against its emission.

关键词： Anaerobic treatment Municipal wastewater Dissolved methane Methane recovery Carbon emission

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Response of organic aerosol characteristics to emission reduction in Yangtze River Delta region

《环境科学与工程前沿（英文）》 2023年第17卷第9期 doi: 10.1007/s11783-023-1714-0

摘要：

● The emission reduction causes significant change in organic aerosol composition.

关键词： Emission control Secondary organic aerosol Atmospheric oxidizing capacity Holiday effects COVID-19 lockdown

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Study on the Path of “Near-zero Emission” Coal-based Clean Energy Ecosystem Development

Zhang Yu-zhuo

《工程管理前沿（英文）》 2014年第1卷第1期页码 37-41 doi: 10.15302/J-FEM-2014007

摘要： Developing a "near-zero emission" coal-based clean energy ecosystem bears great significance for the sustainable development of clean energy in China and the world at large. This article delves into the development strategy, implementation pathways and key priorities of China's "near-zero emission" coal-based clean energy ecosystem, and in turn proposes specific measures to underpin the development and implementation of such system.

关键词： near-zero emission clean energy ecosystem study on the path

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标题作者时间类型操作

Achievements, challenges and global implications of China’s carbon neutral pledge

期刊论文

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

期刊论文

负能量问题——超光速研究的重要方向

黄志洵

期刊论文

Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

期刊论文

Field validation of UHPC layer in negative moment region of steel-concrete composite continuous girder

Minghong QIU; Xudong SHAO; Weiye HU; Yanping ZHU; Husam H. HUSSEIN; Yaobei HE; Qiongwei LIU

期刊论文

Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breastcancer was similar in node-negative diseases: a single-center study of 800 patients

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

期刊论文

硅微z轴谐振陀螺仪负电刚度效应分析及实验验证

夏敦柱,周百令,王寿荣

期刊论文

物理光学的若干进展

黄志洵

期刊论文

大直径盾构负环管片拆除及隧道换装技术

翟志国,黄学军,杨志永

期刊论文

A new prediction method of industrial atmospheric pollutant emission intensity based on pollutant emission